As Takeda works to close its massive Shire buy, the company has unveiled a plan to close its Chicago-area U.S. headquarters and center its U.S. operations in the Boston area where Shire has operations. The move will affect 1,000 employees.

Following a “successful closing” of the Shire buyout, Takeda will “progressively consolidate from Deerfield into the greater Boston area,” spokeswoman Julia Ellwanger said. The deal is subject to shareholder and regulatory approvals, she noted.